Dr. Umesh Kumar
Ph.D. Clinical Metabolomics BBAU / CBMR, Lucknow

Multi-Omics • Biomarker Discovery • Metabolomics

Dr. Umesh Kumar Assistant Professor — SR University, Warangal

Multi-Omics and Biomarker Researcher with 12+ years of expertise in metabolomics, lipidomics, multi-omics integration, NMR spectroscopy, LC-MS/MS, and machine learning for clinical biomarker discovery and precision medicine.

kumarumesh022@gmail.com • +91 9517396699 • Guest Researcher (SGPGIMS, Lucknow)
50+Publications
1,230Citations
21h-index
41i10-index
Email Google Scholar ORCID ResearchGate
Scopus Web of Science Frontiers Loop SciProfiles
01

About Me

Multi-Omics and Biomarker Researcher translating complex biological data into clinical insights.

I am a Multi-Omics and Biomarker Researcher with over 12 years of expertise in Metabolomics, Lipidomics, Multi-Omics Integration, Spatial Omics, and Bioinformatics for multivariate statistical analysis and Machine Learning using Python and R. I am an experienced practitioner of NMR spectroscopy (400–800 MHz), LC-MS/MS, and GC-MS/MS for clinical and pre-clinical biomarker discovery, method development, and large-scale population-based metabolomics.

I hold a PhD in Clinical Metabolomics from Babasaheb Bhimrao Ambedkar University (awarded 2022) through the Centre of BioMedical Research (CBMR), Lucknow, funded by the ICMR-Senior Research Fellowship. My doctoral thesis identified NMR-based metabolic signatures of autoimmune inflammatory diseases including Takayasu arteritis and Lupus Nephritis. I have 50+ peer-reviewed publications (1,230+ citations, h-index 21, i10-index 41), comprising 21 Q1 and 20 Q2 papers, with 9 as first author, 14 as second author, and 12 papers ranked in the top 10 percentile globally.

I qualified four national-level competitive examinations: GATE (2014), ICMR-JRF (2014), CSIR-NET Lectureship (2015), and the UPHESC Assistant Professorship (2022). My international postdoctoral experience at the University of Innsbruck, Austria involved developing SOPs for multi-biofluid metabolomics and processing >1,200 clinical samples under the VASCage programme on vascular health. I am presently Assistant Professor at SR University, Warangal (since July 2026) and continue as Guest Researcher at SGPGIMS, Lucknow.

02

Education

2015 – 2020ICMR-SRF
PhD in Clinical Metabolomics
Babasaheb Bhimrao Ambedkar University (at CBMR), Lucknow
Thesis: Identification of distinctive metabolic signatures of autoimmune inflammatory diseases using NMR based metabolomics approach. Funded by ICMR-Senior Research Fellowship (2018–2020) and ICMR-Junior Research Fellowship (2015–2018).
2010 – 2012
M.Sc. in Biological Sciences
Babasaheb Bhimrao Ambedkar University (BBAU, Central University), Lucknow
2007 – 2010
B.Sc. in Chemistry / Biology
MJP Rohilkhand University, Bareilly
03

Experience

Research and teaching career spanning India, Austria, and multiple premier institutes.

Jul 2026 – Present
Assistant Professor
SR University, Warangal, Telangana — 506371

Teaching Computational Chemistry, Omics Data Analysis, and Machine Learning in Biology at the undergraduate and postgraduate levels. Establishing a state-of-the-art Metabolomics & Multi-Omics Research Facility for biomarker discovery and precision medicine. Mentoring student research projects, guiding interdisciplinary collaborative studies, and developing course curricula for modern bioinformatics and systems biology programmes.

Actively pursuing extramural funding from DST-SERB, ICMR, and UGC for establishing NMR and LC-MS/MS based translational metabolomics platforms. Supervising PhD scholars in multi-omics integration, metabolic pathway analysis, and ML-driven biomarker panel design.

Sep 2024 – Jul 2026
Guest Researcher
Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS), Lucknow
Teaching and practical training in Analytical Research Methods: LC-MS, GC-MS, NMR, Biochemistry, Metabolism, and Multivariate Statistics using Python/R. Conducted metabolomics and lipidomics research on pancreatic cancer and AKI/CKD. Developed LC-MS based SOPs for biofluid metabolomics and lipidomics.
Aug 2024 – Apr 2025
Guest Faculty
NS Postgraduate College, Kanpur University
Taught Human Physiology, Developmental Biology, and Biochemistry to B.Sc. and M.Sc. students. Mentored laboratory practicals and dissertation projects.
Apr 2025 – Jul 2025
Analytical Trainee
Fare Labs Pvt Ltd, India
CRM and stock management; QA/QC support; pesticide/antibiotic residue detection in cereals, milk, and vegetables using LC-MS/MS and GC-MS/MS; method development and instrument troubleshooting.
May 2023 – Jun 2024
Postdoctoral Researcher
University of Innsbruck, Austria
Developed SOPs for stool, saliva, and urine metabolomics (NMR-based). Processed >1,200 clinical samples under VASCage programme. Established collaborations with EUTOPS (TIROLGESUND ATLAS) and Medical University of Innsbruck (NEOVASCage).
Dec 2021 – Mar 2023
Research Associate – III
National Bureau of Animal Genetic Resources (NBAGR), Karnal
Characterized Ladakhi cow and yak colostrum using NMR and LC/GC-MS-based metabolomics. Conducted RNA isolation, antioxidant assays, ELISA, flow cytometry, microscopy, and animal handling. Supervised 1 SRF, 3 PhD scholars, and 1 Master's student.
Sep 2015 – Oct 2021
Senior/Junior Research Fellow (PhD Researcher)
Centre of BioMedical Research (CBMR), Lucknow
Identified metabolic signatures of autoimmune inflammatory diseases (Takayasu arteritis, Lupus Nephritis, MCI). Carried out NMR spectroscopy (400–800 MHz) and multivariate statistical analyses. Mentored 2 PhD scholars and 5 MSc students.
May 2014 – Aug 2015
Project Assistant
Bareilly College (MJPR University) — UGC Project
Specialised in collection and isolation of root-knot nematode. Prepared samples for electron microscopy and SEM analysis. Investigated nematicidal effects of herbal extracts.
2012 – 2013
Business Development Executive
GenxBio Health Sciences Pvt. Ltd.
May – Jul 2011
Summer Intern
Indian Institute of Science (IISc), Bengaluru
Project: Molecular Phylogeny of Hemidactylus brookii species complex in the Himalayas. Performed DNA isolation, electrophoresis, and genetic data analysis.
04

National Examinations

GATE 2014 ICMR-Junior Research Fellowship 2014 CSIR-NET Lectureship 2015 UPHESC Assistant Professorship 2022
05

Technical Skills

Bench, analytical, and computational capabilities for translational metabolomics research.

🧪
NMR-based Metabolomics
  • 1D-NMR (CPMG, ZGPR, NOESY)
  • 2D-NMR (JRES, COSY)
  • 1H-13C NMR (HSQC, HMBC)
  • Topspin
  • Amix Aurelia
  • Chenomx
⚗️
LC-MS/MS & GC-MS/MS
  • HPLC (Agilent, Waters)
  • LC-MS/MS (Agilent, Waters)
  • GC-MS/MS (Shimadzu)
  • Compound Discoverer
  • MassLynx / MassHunter
  • XCMS / Lipid Maps
📊
Bioinformatics & ML
  • Python
  • R
  • MetaboAnalyst
  • SIMCA
  • GraphPad Prism
  • PCA / PLS-DA / OPLS-DA
📦
Databases & Tools
  • HMDB
  • Reactome
  • KEGG
  • Biorender
  • Chem Biodraw
  • Adobe Illustrator
🔬
Analytical Techniques
  • FTIR / UV Spectroscopy
  • ELISA / Antioxidant Assay
  • DNA/RNA Isolation
  • Cell Culture
  • Flow Cytometry
  • Microscopy / SEM
🧬
Biofluid Preparation
  • Serum / Plasma
  • Urine
  • Stool / Saliva
  • Milk / Tissue
  • Colostrum
  • Biofluid Extraction
06

Research Interests

Metabolomics Lipidomics Multi-Omics Integration Spatial Omics Biomarker Discovery NMR Spectroscopy LC-MS/MS GC-MS/MS Machine Learning in Omics Precision Medicine Autoimmune Diseases Cancer Metabolomics Pancreatic Cancer AKI/CKD Gut Microbiota Nutritional Metabolomics Milk Metabolomics Systems Biology
07

Research Projects

🧪
Characterizing Milk Colostrum of Ladakhi Cows and Yak
Identification of biomolecules with therapeutic potential using NMR, LC-MS, and GC-MS analysis. DST-SEED funded project with Dr. Manishi Mukesh (NBAGR).
DST-SEED NBAGR €230K
🔬
Metabolic Signatures of Autoimmune Inflammatory Diseases
NMR-based metabolomics study identifying distinctive metabolic signatures of Takayasu arteritis and Lupus Nephritis. ICMR-funded PhD research at CBMR, Lucknow.
ICMR CBMR €9.7K
🧬
Metabolic Disturbances in Autoimmune Diseases
Disease fingerprinting using NMR-based metabolomics approach for early diagnosis and activity assessment of autoimmune conditions.
ICMR CBMR €10K
🌱
Nematode Management in Vegetable Crops
UGC-funded project studying nematode constraints and their management in Western Uttar Pradesh. Involved field work, electron microscopy, and SEM analysis.
UGC Bareilly College €10.9K
08

Publications

50+ peer-reviewed articles in high-impact journals spanning metabolomics, biomarker discovery, and translational research.

Q1 = Q1 journal • Top 10% = top 10 percentile • IF X.X = Impact Factor • Citations: XX

1H NMR-based serum metabolomics identifies discriminatory metabolic signatures associated with pancreatic cancer
Scientific Reports, 16, 17919 (2026)
Co-author Q1 IF 4.9 [DOI]
Characterization of metabolite profiles in milk derived exosomes from indicus, crossbred and taurine cows by 1H NMR analysis
Food Chemistry, 473, 143015 (2025)
Q1 Top 10% IF 10.4 [DOI]
Characterizing metabolome signature of colostrum, transition and mature milk of indigenous cows adapted to high altitude
Food Chemistry, 464, 141767 (2025)
Q1 Top 10% IF 10.4 [DOI]
Multi-modal atlas of lifestyle interventions reveals malleability of ageing-linked molecular features
Cell (under review) • bioRxiv (2025)
IF 64.5 [DOI]
Systemic multi-omic remodelling underlies health benefits of intermittent fasting
bioRxiv (2025)
IF 64.5 [DOI]
Longitudinal multi-omic evaluation of biomarkers of health and ageing over smoking cessation intervention
bioRxiv (2025)
IF 64.5 [DOI]
Kuwanons from Mulberry (Morus spp.): Exploring structural activity relationship, biosynthesis, and biological properties
Fitoterapia, 190, 107138 (2026)
IF 2.5[DOI]
Mulberry: From nutraceuticals to bioactive phytochemicals
Food and Humanity, 2, 100272 (2024)
IF 2.1[DOI]
Acute pancreatitis is characterized by generalized intestinal barrier dysfunction in early stage
Pancreatology, 23(1), 9-17 (2023)
Citations: 37IF 3.6[DOI]
Silk fibroin hydrogel: A novel biopolymer for sustained release of vancomycin drug for diabetic wound healing
Journal of Molecular Structure, 1286, 135548 (2023)
Citations: 30IF 3.8[DOI]
Fabrication of mulberry leaf extract (MLE)- and tasar pupal oil (TPO)-loaded silk fibroin hydrogels and their antimicrobial properties
3 Biotech, 13, 37 (2023)
IF 2.6[DOI]
Vinpocetine mitigates DMH-induced pre-neoplastic colon damage in rats through inhibition of pro-inflammatory cytokines
International Immunopharmacology, 119, 110236 (2023)
IF 4.8[DOI]
Association of altered metabolic profiles and long non-coding RNAs expression with disease severity in breast cancer patients
Metabolomics, 19, 8 (2023)
IF 3.6[DOI]
Ameliorative effect of fluvoxamine against colon carcinogenesis via COX-2 blockade with oxidative and metabolic stress reduction
BBA Advances, 2, 100046 (2022)
IF 2.8[DOI]
Assessment of hyaluronic acid-modified imatinib mesylate cubosomes through CD44 targeted drug delivery in NDEA-induced hepatic carcinoma
International Journal of Pharmaceutics, 622, 121848 (2022)
Citations: 26IF 5.8[DOI]
Mechanistic exploration of poly(lactic-co-glycolic acid)-loaded nanoparticles of betulinic acid against hepatocellular carcinoma
Archives of Physiology and Biochemistry, 128(3), 836-848 (2022)
IF 3.5[DOI]
Response Guided Slow Infusion of Albumin, Vasoconstrictors and Furosemide Improves Ascites Mobilization and Survival in Acute on Chronic Liver Failure
Journal of Inflammation Research, 2022, 5027-5039 (2022)
IF 4.5[DOI]
An elaborative NMR based plasma metabolomics study revealed metabolic derangements in patients with mild cognitive impairment
Metabolic Brain Disease, 36, 957-968 (2021)
IF 3.6[DOI]
Circulatory histidine levels as predictive indicators of disease activity in Takayasu arteritis
Analytical Science Advances, 2(11-12), 527-535 (2021)
IF 2.0[DOI]
Fabrication of Imatinib Mesylate-Loaded Lactoferrin-Modified PEGylated Liquid Crystalline Nanoparticles for Mitochondrial-Dependent Apoptosis in HCC
Molecular Pharmaceutics, 18(3), 1102-1120 (2021)
Citations: 27IF 4.9[DOI]
NMR-based serum and muscle metabolomics for diagnosis and activity assessment in idiopathic inflammatory myopathies
Analytical Science Advances, 2(11-12), 515-526 (2021)
IF 2.0[DOI]
Serum Metabolic Disturbances Associated with Acute-on-chronic Liver Failure in Patients with Alcoholic Liver Diseases
Journal of Pharmacy and Bioallied Sciences, 13(2), 276-282 (2021)
IF 0.6[DOI]
Targeted NMR-based serum metabolic profiling of serine, glycine and methionine in acute-on-chronic liver failure patients
Analytical Science Advances, 2(11-12), 536-545 (2021)
IF 2.0[DOI]
Characterization, biological evaluation and molecular docking of mulberry fruit pectin
Scientific Reports, 10, 21789 (2020)
Q1Citations: 32IF 4.9[DOI]
Circulatory Glutamine/Glucose ratio for evaluating disease activity in Takayasu arteritis: A NMR based serum metabolomics study
Journal of Pharmaceutical and Biomedical Analysis, 180, 113080 (2020)
Citations: 40IF 3.4[DOI]
Nuclear magnetic resonance-based targeted profiling of urinary acetate and citrate following cyclophosphamide therapy in lupus nephritis
Lupus, 29(7), 782-786 (2020)
Q1Top 10%IF 2.6[DOI]
Novel 1,3,4-thiadiazoles inhibit colorectal cancer via blockade of IL-6/COX-2 mediated JAK2/STAT3 signals
Cytokine, 118, 144-159 (2019)
Citations: 58IF 3.8[DOI]
Metabolomics approach discriminates toxicity index of pyrazinamide and its metabolic products, pyrazinoic acid and 5-hydroxy pyrazinoic acid
Human & Experimental Toxicology, 37(4), 373-389 (2018)
Citations: 43IF 2.9[DOI]
NMR-Based Serum Metabolomics Reveals Reprogramming of Lipid Dysregulation Following Cyclophosphamide-Based Induction Therapy in Lupus Nephritis
Journal of Proteome Research, 17(7), 2440-2448 (2018)
Q1Citations: 35IF 3.8[DOI]
NMR-Based Serum Metabolomics of Patients with Takayasu Arteritis: Relationship with Disease Activity
Journal of Proteome Research, 17(9), 3317-3324 (2018)
Q1Citations: 25IF 3.8[DOI]
Novel 1,4-benzothazines obliterate COX-2 mediated JAK-2/STAT-3 signals with potential regulation of oxidative and metabolic stress during colorectal cancer
Pharmacological Research, 132, 188-203 (2018)
Q1Top 10%Citations: 23IF 12.2[DOI]

Full list: Google Scholar

09

Memberships & Editorial Roles

Professional Memberships
NMRS (Life Member) TBRSI (Founder Member) ISETF (Life Member) APNMR (Life Member)
Editorial & Peer Review

Reviewing Editor — Molecular Diagnostics & Therapeutics

Review Editor — Frontiers in Molecular Biosciences

10

Supervision & Mentoring

At CBMR (Doctoral Training)
  • Mentored 2 PhD scholars in metabolomics-based dissertation research
  • Mentored 5 MSc students in NMR-based metabolomics projects
At NBAGR (Research Associate)
  • Supervised 1 Senior Research Fellow
  • Supervised 3 PhD scholars
  • Supervised 1 Master's student

Academic Administration: Served as Examination Centre In-Charge Officer (3 times) for undergraduate and postgraduate examinations conducted by CSJM University.

11

Awards & Recognitions

ICMR-Junior Research Fellowship (2015) ICMR-Senior Research Fellowship (2018) CSIR-NET Lectureship (2015) UPHESC Assistant Professor (2022) ICMR Travel & Workshop Grants Best Oral/Poster Presentation Awards 2 Invited Lectures 7 Oral & Poster Presentations
12

Key Collaborators

Dr. Dinesh Kumar (CBMR, Lucknow) Dr. Anupam Guleria (CBMR, Lucknow) Dr. Manishi Mukesh (ICAR-NBAGR) Prof. Martin Widschwendter (EUTOPS, Austria) Medical University of Innsbruck (NEOVASCage) Dr. Subash Chandra Gupta (BHU) Dr. Narayan Prasad (SGPGIMS) Dr. Gaurav Pandey (SGPGIMS) Dr. Atul Rawat (SGPGIMS)
13

Research Vision

~ Umesh

"My long-term goal is to lead innovative metabolomics research that uncovers disease mechanisms, identifies clinically actionable biomarkers, and accelerates the translation of omics science into personalized healthcare solutions."

14

Get in Touch

Open to research collaborations, academic discussions, and partnership opportunities in metabolomics, biomarker discovery, and multi-omics integration.

Email kumarumesh022@gmail.com Phone +91 9517396699 Google Scholar View Profile ORCID 0000-0002-0961-8048 ResearchGate View Profile